منابع مشابه
Potassium leakage during the apoptotic degradation phase.
The subcellular compartmentalization of ions is perturbed during the process of apoptosis. In this work, we investigated the impact of K+ on the apoptotic process in thymocytes and T cell hybridoma cells. Irrespective of the death-inducing stimulus (glucocorticoids, topoisomerase inhibition, or Fas-crosslinking), a significant K+ outflow was observed during apoptosis, as determined on the singl...
متن کاملanaerobic brain abscess
background: brain abscess remains a potentially fatal central nervous system (cns) disease, especially in developing countries. anaerobic abscess is difficult to diagnose because of cumbersome procedures associated with the isolation of anaerobes. materials and methods: this is a hospital-based retrospective microbiological analysis of 430 brain abscess materials (purulent aspirates and/or tiss...
متن کاملAnaerobic brain abscess
BACKGROUND AND OBJECTIVES Brain abscess remains a potentially fatal central nervous system (CNS) disease, especially in developing countries. Anaerobic abscess is difficult to diagnose because of cumbersome procedures associated with the isolation of anaerobes. MATERIALS AND METHODS This is a hospital-based retrospective microbiological analysis of 430 brain abscess materials (purulent aspira...
متن کاملMechanisms of antihistamine-induced sedation in the human brain: H1 receptor activation reduces a background leakage potassium current.
Antihistamines, more formally termed H1 receptor antagonists, are well known to exert sedative effects in humans, yet their locus and mechanism of action in the human brain remains unknown. To better understand this phenomenon, the effects of histamine upon human cortical neurons were studied using intracellular recordings in brain slices maintained in vitro. Bath application of 50 microM hista...
متن کاملPotassium channels in brain mitochondria.
Potassium channels are the most widely distributed class of ion channels. These channels are transmembrane proteins known to play important roles in both normal and pathophysiological functions in all cell types. Various potassium channels are recognised as potential therapeutic targets in the treatment of Parkinson's disease, Alzheimer's disease, brain/spinal cord ischaemia and sepsis. In addi...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1949
ISSN: 0306-3283
DOI: 10.1042/bj0440187